Table 3. Background Exercise can induce a transient increase in urinary protein excretion. The aim of this study was to determine the effects of different intensities of aerobic exercise on proteinuria in hypoxia and normoxia conditions in young football players.
It is concluded that aerobic exercise at the height of m above sea may have no effect on proteinuria, compared to lower elevations. Aerobic exercise. Palabras clave:. Texto completo. Introduction Large proteins, such as globulins and albumin cannot pass through the glomerular membrane GM and therefore, are detected in very small amounts in urine, unless glomerular damage results in glomerular proteinuria.
Materials and methods Subjects The study sample consisted of 10 young male soccer players whose physical characteristics are presented in Table 1. Poortmans, M.
Glomerular filtration rate and albumin excretion after maximal exercise in aging sedentary and active men. Poortmans, N. Mathieu, P. De Plaen. Influence of running different distances on renal glomerular and tubular impairment in humans.
Kocer, U. Senturk, O. Kuru, F. Potential sources of oxidative stress that induce post-exercise proteinuria in rats. J Appl Physiol, 10 , pp. Von Leube. Virkows Arch Pathol Anat Physiol, 72 , pp. Evidence of increased glomerular permeability to proteins during exercise in healthy man. Contrib Nephrol, 68 , pp. Boileau, E. Fuchs, J. Barry, C. Stress hematuria: athletic pseudonephritis in marathoners.
Urology, 15 , pp. Post-exercise proteinuria in humans: facts and mechanisms. JAMA, , pp. Creeth, R. Kekwick, F. Flynn, H. Harris, E. An ultracentrifuge study of urine proteins with particular reference to the proteinuria of renal tubular disorders. Clin Chim Acta, 8 , pp. Estivi, R. Urbino, C. Tetta, G. Pagano, P. Urinary protein excretion induced by exercise: effect of a mountain agonistic footrace in healthy subjects, renal function and mountain footrace. J Sports Med Phys Fitness, 39 , pp.
Sport Med, 1 , pp. Zambraski, M. Bober, J. Goldstein, C. Lakas, M. Changes in renal cortical sialic acids and colloidal iron staining associated with exercise. Med Sci Sports Exerc, 13 , pp. Alyea, H. Renal responses to exercise: urinary findings. It is often missed on dipstick testing, which detects only albumin. This type of proteinuria is usually seen in tubulointerstitial diseases or in patients with idiopathic nephrotic syndrome.
Overflow proteinuria occurs when small molecular light chains escape the glomerular filtration barrier and overwhelm the tubular reabsorptive capacity. This type of proteinuria can be seen in multiple myeloma, and is detectable by protein-to-creatinine ratio or urine protein electrophoresis.
The root cause of exercise-induced proteinuria is unclear, but the renin-angiotensin system RAS and prostaglandins are thought to play a major role. The plasma concentration of angiotensin II increases during exercise, leading to filtration of protein through the glomerular membrane. Also, strenuous exercise increases sympathetic nervous system activity as well as blood levels of catecholamines, thereby increasing permeability of the glomerular capillary membrane.
Because microalbuminuria is not detectable by a standard urine dipstick test, some providers routinely screen for protein with the microalbumin-to-creatinine ratio. A first-voided morning urine specimen is recommended, but random urine samples are an acceptable alternative. Lactic acidosis, generated during anaerobic conditions, causes the passage of erythrocytes into the urine, through increased glomerular permeability. Abstract Proteinuria and hematuria are common during exercise.
Substances Cytokines. The physical examination and other laboratory values were unremarkable. How concerned should you be about the finding of proteinuria? Exercise-induced proteinuria is generally benign and a function of the intensity--rather than the duration--of exercise.
The normal range of protein excretion in healthy individuals is to mg of protein per day, of which albumin constitutes 10 to 20 mg. Diverse processes leading to proteinuria--working alone or concomitantly--occur at the level of the nephron. This type of proteinuria can occur with different glomerulopathies, upright posture, or exercise. Researchers have not identified the mechanisms leading to postexercise proteinuria, but there are several theories. For more on this, see "Why does exercise increase protein excretion?
This results in the escape of [beta]2-microglobulin and immunoglobulin light chains from proximal tubular reabsorption.
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